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VIDEO ECOGRAFIA
: A large ovarian mass that extends for approximately 11cm X 8cm.
The lesion present inhomogeneous echostructure with large, regular, cystic areas in the context.
The solid component present little vascular flow .

VIDEO TC : CT scan demonstrates a large right ovarian mass with solid and cystic components , that displacement least the bladder, with little enhancement in solid component.





HISTOLOGY
The cells are arranged in intersecting bundles.
There is prominent edema.
The tumor is cellular but devoid of significant atipia.
Rare mitotic figure is evident ( < 3 x 10HPF).
Note elements pseudocystic degeneration .

Clinical Cases
PRESENTATION

The most common benign solid tumor of the ovary is the fibroma ( about the 4% of all ovarian tumors )
Fibromas are derived from connective tissue and arise from the solid ovarian cortical stroma.
The stroma of the ovary consists of undifferentiated mesenchymal cells and their endocrine derivatives.
Fibromas, thecomas, fibrosed thecomas, and fibrothecomas are ovarian tumors of gonadal stromal origin and may be variants of a single entity.

Cellular fibroma of Ovary is an uncommon benign ovarian neoplasms.

It mimics fibrosarcoma histologically because of its rich cellularity and high number of mitoses.
Cellular fibroblastic tumors of the ovary are currently classified as either cellular fibroma or fibrosarcoma. The former are characterized by bland nuclei, 3 or fewer mitotic figures per 10 high-power fields
Women with these tumors are generally asymptomatic, and masses are typically detected in middle-aged women at palpation during routine gynecologic examination. A gain of trisomy 12 cells has been demonstrated by FISH in eight of these tumor.

Greater than 90% are unilateral, and approximately 10-15% are found in association with ascites.
One percent of cases are associated with Meigs syndrome, characterized by ovarian fibroma, ascites, and pleural effusion.

Ultrasonographically, these tumors appear hypoechoic with attenuation of the ultrasound beam.
CT demonstrates a well-defined solid homogeneous or mildly heterogenous mass with little or no enhancement.
The tumours can grow to a large size and demonstrate cystic degeneration and dystrophic calcification.
The malignant potential is reported to be under 1%.



FINAL DIAGNOSIS :

Cellular Fibroma of the ovary


REFFERENCES :

Pathology of the Ovary Jaime Prat MD, FRCPath; SAUNDERS Cellular fibromas and fibrosarcomas of the ovary: A comparative clinicopathologic analysis of seventeen cases. Jaime Prat and Robert E. Scully (Cancer, 1981. 47(11): 2663-2670 Cellular fibromas of the ovary: a study of 75 cases including 40 mitotically active tumors emphasizing their distinction from fibrosarcoma. Irving, JA., Alkushi A, Young RH and Clement PB. (Am J Surg Pathol, 2006. 30(8): 929-38)

 

Cellular Fibroma of the ovary
FIBROMA OVARICO CELLULATO
Autori:
Dott. Danilo Sirigu*; Dott.ssa Giovanna Sardu* ;Dott. Marco Carta**
*A.O.Brotzu (Cagliari ) ** A.S.L. 8 (Cagliari )

Novembre 2007
www.ecomovies.it

E-mail: info@radmovies.it
 
 
 
Clinic cases:
> Primary adenocarcinoma of the duodenum
> Virtual colonscopy
> HEPATIC ECHINOCOCCUS CYST
> Budd Chiari Syndrome
>THE GRAFT INTOLERANCE SYNDROME ( GIS )
> Cellular Fibroma of the ovary
> Von Meyenburg complexes
>SPONTANEOUS BACTERIAL PERITONITIS
 
 
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